Mechanisms of the improvement in peak VO2 with exercise training in heart failure with reduced or preserved ejection fraction
WJ Tucker, CC Lijauco, CM Hearon Jr… - Heart, Lung and …, 2018 - Elsevier
Heart failure (HF) is a major health care burden associated with high morbidity and mortality.
Approximately 50% of HF patients have reduced ejection fraction (HFrEF) while the
remainder of patients have preserved ejection fraction (HFpEF). A hallmark of both HF
phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary to
impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training is a
safe and effective intervention to improve peak oxygen uptake (VO 2peak) and quality of life …
Approximately 50% of HF patients have reduced ejection fraction (HFrEF) while the
remainder of patients have preserved ejection fraction (HFpEF). A hallmark of both HF
phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary to
impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training is a
safe and effective intervention to improve peak oxygen uptake (VO 2peak) and quality of life …
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