Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event

TW Geisbert, HA Young, PB Jahrling… - The Journal of …, 2003 - academic.oup.com
Disseminated intravascular coagulation is a prominent manifestation of Ebola virus (EBOV)
infection. Here, we report that tissue factor (TF) plays an important role in triggering the
hemorrhagic complications that characterize EBOV infections. Analysis of samples obtained
from 25 macaques showed increased levels of TF associated with lymphoid macrophages,
whereas analysis of peripheral blood–cell RNA showed increased levels of TF transcripts by
day 3. Plasma from macaques contained increased numbers of TF-expressing membrane …

[引用][C] Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key …

G TW - J Infect Dis, 2003 - cir.nii.ac.jp
Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever :
overexpression of tissue factor in primate monocytes/macrophages is a key event | CiNii
Research … Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever
: overexpression of tissue factor in primate monocytes/macrophages is a key event …
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