Mechanistic basis of co-stimulatory CD40-CD40L ligation mediated regulation of immune responses in cancer and autoimmune disorders
Generation of an accurate humoral and a cell mediated adaptive immune responsesare
dictated by binding of an antigen to a T-and a B-cell receptor, respectively (first signal)
followed by ligation of costimulatory molecules (second signal). CD40, a costimulatory
receptor molecule, expressed mainly on antigen presenting cells, some non-immune cells
and tumors, binds to CD40 ligand molecule expressed transiently on T-cells and non-
immune cells under inflammatory conditions. In the past decade, the CD40-CD40L …
dictated by binding of an antigen to a T-and a B-cell receptor, respectively (first signal)
followed by ligation of costimulatory molecules (second signal). CD40, a costimulatory
receptor molecule, expressed mainly on antigen presenting cells, some non-immune cells
and tumors, binds to CD40 ligand molecule expressed transiently on T-cells and non-
immune cells under inflammatory conditions. In the past decade, the CD40-CD40L …
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