… reveal extensive disruption of cellular protein interaction networks resulting from … substrate
degradome atlas provides a powerful resource to inspire mechanistic studies of COVID-19 …

… Since the onset of COVID-19, 3CLpro has been considered as … 3CLpro host cell degradome,
it nonetheless provides insight … Mechanistic insights into COVID-19 by global analysis of the …

… process of COVID-19. Small-molecule compounds targeting … substrate map of SARS-CoV-2
3CL protease. Citation20 … insights into the study of drugs that target the SARS-CoV-2 …

… Here, we expand the interactome and degradome of 3CLpro … 3 substrate targets of the
SARS-CoV-2 Nsp5-encoded 3CLpro … pathogenesis of COVID-19 and the therapeutic reduction of …

… syndrome (MERS), and COVID-19, have posed a significant … in this study and those identified
in vitro SARS-CoV-2 3CL pro … pro substrate degradome, we categorized these proteins into …

… The SARS-CoV-2 M pro protease from COVID-19 cleaves the pp1a and pp2b polyproteins
… The information reported here has not only provided insight into the relative preferences for …

… Coronavirus disease 2019 (COVID-19), caused by the … Mpro is also referred to as 3-chymotrypsin-like
protease (3CLpro). … complexes, the substrate envelope of SARS-CoV-2 Mpro was …

… COVID-19 pandemic, 3CLpro has become the focus of numerous drug discovery efforts
worldwide. … the overall effect of 3CLpro-mediated broad host substrate cleavages on cells will be …

… 3CL pro is expressed in the cells, it will cleave its substrate to distance the pEYFP and Rluc
… to fully define the potential inhibitors for COVID-19 treatments, this work provides a robust …

… 2019 (COVID-19) in the first documented coronavirus pandemic (1). With SARS-CoV-2 now
… The structural insights gleaned from global analysis of >800 cleavage sites identified by …