Megahertz serial crystallography

MO Wiedorn, D Oberthür, R Bean, R Schubert… - Nature …, 2018 - nature.com
… We demonstrate here that serial femtosecond crystallography using bursts of megahertz
repetition rate X-ray pulses is capable of high-resolution structure determination using high-…

[PDF][PDF] Rapid sample delivery for megahertz serial crystallography at X-ray FELs

MO Wiedorn, S Awel, AJ Morgan, K Ayyer, Y Gevorkov… - IUCrJ, 2018 - journals.iucr.org
… With the advent of X-ray FELs with megahertz rates, the … This work reports the results of
a megahertz serial diffraction … The results indicate the feasibility for megahertz serial crystal…

[HTML][HTML] Evaluation of serial crystallographic structure determination within megahertz pulse trains

O Yefanov, D Oberthür, R Bean, MO Wiedorn… - Structural …, 2019 - pubs.aip.org
The new European X-ray Free-Electron Laser (European XFEL) is the first X-ray free-electron
laser capable of delivering intense X-ray pulses with a megahertz interpulse spacing in a …

Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers

S Holmes, HJ Kirkwood, R Bean… - Nature …, 2022 - nature.com
… ) II are extremely intense sources of X-rays capable of generating Serial Femtosecond
Crystallography (SFX) data at megahertz (MHz) repetition rates. Previous work has shown that it is …

Membrane protein megahertz crystallography at the European XFEL

C Gisriel, J Coe, R Letrun, OM Yefanov… - Nature …, 2019 - nature.com
serial femtosecond crystallography (SFX), leveraging orders-of-magnitude faster data collection.
Here, we report the first membrane protein megahertz … challenges to megahertz SFX for …

Observation of shock-induced protein crystal damage during megahertz serial femtosecond crystallography

ML Grünbein, L Foucar, A Gorel, M Hilpert, M Kloos… - Physical Review …, 2021 - APS
Shock waves launched by x-ray pulses in sample-carrying liquid jets may affect protein
crystallography data collected at MHz repetition rate x-ray free-electron laser (XFEL) facilities, by …

Chemical crystallography by serial femtosecond X-ray diffraction

EA Schriber, DW Paley, R Bolotovsky, DJ Rosenberg… - Nature, 2022 - nature.com
… Here we demonstrate small-molecule serial femtosecond X-ray crystallography (smSFX) for
the … After indexing the sparse serial patterns by a graph theory approach 14 , the resulting …

Serial femtosecond crystallography

TRM Barends, B Stauch, V Cherezov… - Nature reviews Methods …, 2022 - nature.com
… single-crystal rotation crystallography by mitigating … serial crystallography in planning and
carrying out a successful SFX experiment. It discusses the background of serial crystallography

Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison

P Mehrabi, R Bücker, G Bourenkov, HM Ginn… - Science …, 2021 - science.org
… , we present a systematic comparison of crystallographic diffraction data collected by serial
femtosecond (SFX) and serial synchrotron crystallography (SSX). To maximize comparability, …

A guide to sample delivery systems for serial crystallography

FZ Zhao, B Zhang, EK Yan, B Sun, ZJ Wang… - The FEBS …, 2019 - Wiley Online Library
… For traditional crystallography experiments, the growth of … application of serial femtosecond
crystallography (SFX) … SFX has been expanded to serial crystallography (SX) that can …