… The pleiotropic activities of the cutaneous melatoninergic system are mediated by cell-… skin
integrity, and perhaps affecting body’s homeostasis (Fig. 3.2). Local melatoninergic systems …

… skin is not only a target for the protective actions of melatonin, but also a site of melatonin
synthesis and metabolism, suggesting an important role for a local melatoninergic system … skin …

… In this review we summarize data on a skin serotoninergic/melatoninergic system generated
in vitro and in vivo. Then we examine a potential role for this system in skin’s physiology …

… skin and in cultured normal and malignant melanocytes and immortalized keratinocytes;
HIOMT activity was detected in human skin, … that the human skin expresses intrinsic serotonin …

… /melatoninergic system, we investigated expression of the genes for the 5HT and MT and
MRR receptors in whole skin and cultured skin … , and 5MTT in selected cultured cell systems. …

… human and rodent skin and in the major cutaneous cellular populations (5). Therefore,
we have proposed that the expression of a cutaneous melatoninergic system would serve to …

… system. Recent research has revealed that mammalian skin also harbors a complex
melatoninergic system, … Unlike the pineal melatoninergic system, its intracutaneous counterpart is …

… melatonin against UV solar skin damage are mainly mediated … The effects of the main
environmental skin stressor, UV … melatoninergic antioxidative system (MAS) of the skin, with UV …

… role of melatonin and its metabolites in human skin, we investigated skin cell type-specific
melatonin … differentiation, using a recently characterized human skin organ culture system (40). …

… Local melatoninergic system in skin includes sequential transformation of tryptophan to
serotonin and melatonin. NAS is both precursor and metabolite of melatonin. Through indolic …