Transplantation of cryopreserved ovarian tissue is a novel technique to restore endocrine
function and fertility especially for cancer patients. However, the main obstacle of the
technique is massive follicle loss as a result of ischemia in the process of transplantation.
Mesenchymal stem cells (MSCs) have been acknowledged to play an important role in
supporting angiogenesis and stabilizing long-lasting blood vessel networks through release
of angiogenic factors and differentiation into pericytes and endothelial cells. This study is …

Objective Since the main obstacle of the cryopreserved ovarian tissue transplantation is
massive follicle loss as a result of ischemia in the process of transplantation, this study is
aimed to investigate whether mesenchymal stem cells (MSCs) could be applied to enhance
the angiogenesis and follicle survival in human cryopreserved ovarian cortex
transplantation. Design We transplanted human cryopreserved ovarian cortex tissues with
MSCs in the subcutaneous of female athymic BALB/c mice. At different time points, vascular …