NME1 (also known as NM23-H1) was the first identified tumor metastasis suppressor, which
has been reported to link with genomic stability maintenance and cancer. However its
underlying mechanisms are still not fully understood. Here we find that NME1 is required for
non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Mechanistically,
NME1 re-localizes to DNA damage sites in a Ku-XRCC4-dependent manner, and regulates
downstream LIG4 recruitment and end joining efficiency. Furthermore, we show that the 3 …