Metformin effects on head and neck squamous carcinoma microenvironment: window of opportunity trial
Objective The tumor microenvironment frequently displays abnormal cellular metabolism,
which contributes to aggressive behavior. Metformin inhibits mitochondrial oxidative
phosphorylation, altering metabolism. Though the mechanism is unclear, epidemiologic
studies show an association between metformin use and improved outcomes in head and
neck squamous cell carcinoma (HNSCC). We sought to determine if metformin alters
metabolism and apoptosis in HNSCC tumors. Study Design Window of opportunity trial of …
which contributes to aggressive behavior. Metformin inhibits mitochondrial oxidative
phosphorylation, altering metabolism. Though the mechanism is unclear, epidemiologic
studies show an association between metformin use and improved outcomes in head and
neck squamous cell carcinoma (HNSCC). We sought to determine if metformin alters
metabolism and apoptosis in HNSCC tumors. Study Design Window of opportunity trial of …
[引用][C] Metformin effects on head and neck squamous carcinoma microenvironment: window of opportunity trial
MD Tassone - 2017 - jdc.jefferson.edu
"Metformin effects on head and neck squamous carcinoma microenvironment" by Patrick
Tassone, MD, PGY-4 … Tassone, MD, PGY-4, Patrick, "Metformin effects on head and neck
squamous carcinoma microenvironment: window of opportunity trial" (2017). Department of
Otolaryngology - Head and Neck Surgery Presentations and Grand Rounds. Presentation 75. …
Tassone, MD, PGY-4 … Tassone, MD, PGY-4, Patrick, "Metformin effects on head and neck
squamous carcinoma microenvironment: window of opportunity trial" (2017). Department of
Otolaryngology - Head and Neck Surgery Presentations and Grand Rounds. Presentation 75. …
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