Background Steroids remain the first-choice therapeutic in sarcoidosis; however, long-term
use is associated with toxicity. Evidence defining the best second-line therapeutic is
currently lacking. The aim of this study was to compare the effect of methotrexate and
azathioprine on prednisone tapering, pulmonary function, and side effects in the second-line
treatment of sarcoidosis. Methods An international retrospective cohort study was performed,
reviewing all patients with sarcoidosis who started methotrexate or azathioprine until 2 years …