Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo
Many flaviviruses including the Dengue virus (DENV), Zika virus (ZIKV), West Nile virus,
Yellow Fever virus, and Japanese encephalitis virus are significant human pathogens,
unfortunately without any specific therapy. Here, we demonstrate that methylene blue, an
FDA-approved drug, is a broad-spectrum and potent antiviral against Zika virus and Dengue
virus both in vitro and in vivo. We found that methylene blue can considerably inhibit the
interactions between viral protease NS3 and its NS2B co-factor, inhibit viral protease activity …
Yellow Fever virus, and Japanese encephalitis virus are significant human pathogens,
unfortunately without any specific therapy. Here, we demonstrate that methylene blue, an
FDA-approved drug, is a broad-spectrum and potent antiviral against Zika virus and Dengue
virus both in vitro and in vivo. We found that methylene blue can considerably inhibit the
interactions between viral protease NS3 and its NS2B co-factor, inhibit viral protease activity …
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