Mice with deleted multimerin 1 and α-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1
BACKGROUND: Multimerin 1 is a stored platelet and endothelial cell adhesive protein that
shows significant conservation. In vitro, multimerin 1 supports platelet adhesion and it also
binds to collagen and enhances von Willebrand factor-dependent platelet adhesion to
collagen. As selective, multimerin 1 deficient mice have not been generated, we investigated
multimerin 1 effects on platelet adhesion using a subpopulation of C57BL/6J mice with
tandem deletion of the genes for multimerin 1 and α-synuclein, a protein that inhibits α …
shows significant conservation. In vitro, multimerin 1 supports platelet adhesion and it also
binds to collagen and enhances von Willebrand factor-dependent platelet adhesion to
collagen. As selective, multimerin 1 deficient mice have not been generated, we investigated
multimerin 1 effects on platelet adhesion using a subpopulation of C57BL/6J mice with
tandem deletion of the genes for multimerin 1 and α-synuclein, a protein that inhibits α …
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