MicroRNA regulatory networks reflective of polyhexamethylene guanidine phosphate-induced fibrosis in A549 human alveolar adenocarcinoma cells
Polyhexamethylene guanidine phosphate (PHMG-phosphate), an active component of
humidifier disinfectant, is suspected to be a major cause of pulmonary fibrosis. Fibrosis,
induced by recurrent epithelial damage, is significantly affected by epigenetic regulation,
including microRNAs (miRNAs). The aim of this study was to investigate the fibrogenic
mechanisms of PHMG-phosphate through the profiling of miRNAs and their target genes.
A549 cells were treated with 0.75 μg/mL PHMG-phosphate for 24 and 48 h and miRNA …
humidifier disinfectant, is suspected to be a major cause of pulmonary fibrosis. Fibrosis,
induced by recurrent epithelial damage, is significantly affected by epigenetic regulation,
including microRNAs (miRNAs). The aim of this study was to investigate the fibrogenic
mechanisms of PHMG-phosphate through the profiling of miRNAs and their target genes.
A549 cells were treated with 0.75 μg/mL PHMG-phosphate for 24 and 48 h and miRNA …
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