MicroRNA-19b restricts Wnt7b to the hem, which induces aspects of hippocampus development in the avian forebrain
The functions of the hippocampus are conserved between birds and mammals; however, it
is not known whether similar mechanisms are responsible for its development in these two
classes. In mammals, hippocampus development is known to be regulated by the hem
organizer. Here, we have identified that, in birds, Wnt7b secreted from the hem is sufficient
for inducing the expression of hippocampal markers. Furthermore, we have demonstrated
that a microRNA, miR-19b, which is selectively excluded from the hem region, is necessary …
is not known whether similar mechanisms are responsible for its development in these two
classes. In mammals, hippocampus development is known to be regulated by the hem
organizer. Here, we have identified that, in birds, Wnt7b secreted from the hem is sufficient
for inducing the expression of hippocampal markers. Furthermore, we have demonstrated
that a microRNA, miR-19b, which is selectively excluded from the hem region, is necessary …
[PDF][PDF] Correction: MicroRNA-19b restricts Wnt7b to the hem, which induces aspects of hippocampus development in the avian forebrain
SK Sindhu, N Udaykumar, MAA Zaidi… - Development …, 2020 - academia.edu
The functions of the hippocampus are conserved between birds and mammals; however, it
is not known whether similar mechanisms are responsible for its development in these two
classes. In mammals, hippocampus development is known to be regulated by the hem
organizer. Here, we have identified that, in birds, Wnt7b secreted from the hem is sufficient
for inducing the expression of hippocampal markers. Furthermore, we have demonstrated
that a microRNA, miR-19b, which is selectively excluded from the hem region, is necessary …
is not known whether similar mechanisms are responsible for its development in these two
classes. In mammals, hippocampus development is known to be regulated by the hem
organizer. Here, we have identified that, in birds, Wnt7b secreted from the hem is sufficient
for inducing the expression of hippocampal markers. Furthermore, we have demonstrated
that a microRNA, miR-19b, which is selectively excluded from the hem region, is necessary …
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