MiRNAs regulate cardiac development, hypertrophy, and angiogenesis, but their role in
cardiac hypertrophy (CH) induced by aerobic training has not previously been studied.
Aerobic training promotes physiological CH preserving cardiac function. This study
assessed involvement of miRNAs-29 in CH of trained rats. Female Wistar rats (n= 7/group)
were randomized into three groups: sedentary (S), training 1 (T1), training 2 (T2). T1:
swimming sessions of 60 min/5 days/wk/10 wk. T2: similar to T1 until 8th wk. On the 9th wk …

Soci UPR, Fernandes T, Hashimoto NY, Mota GF, Amadeu MA, Rosa KT, Irigoyen MC,
Phillips MI, Oliveira EM. MicroRNAs 29 are involved in the improvement of ventricular
compliance promoted by aerobic exercise training in rats. Physiol Genomics 43: 665–673,
2011. First published March 29, 2011; doi: 10.1152/physiolgenomics. 00145.2010.—
MiRNAs regulate cardiac development, hypertrophy, and angiogenesis, but their role in
cardiac hypertrophy (CH) induced by aerobic training has not previously been studied …