[HTML][HTML] MicroRNAs and current concepts on the pathogenesis of abdominal aortic aneurysm

EE Joviliano, MS Ribeiro, EJR Tenorio - Brazilian Journal of …, 2017 - SciELO Brasil
Brazilian Journal of Cardiovascular Surgery, 2017SciELO Brasil
Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the
elderly. Currently, the only way to prevent rupture and death related to abdominal aortic
aneurysms is through surgical intervention. Endovascular treatment is associated with less
morbidity than conventional treatment. The formation of an aneurysm is a complex
multifactorial process, involving destructive remodeling of the connective tissue around the
affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs …
Abstract
Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a complex multifactorial process, involving destructive remodeling of the connective tissue around the affected segment of the aorta wall. MicroRNAs are small sequences of non-coding RNAs that control diverse cellular functions by promoting degradation or inhibition of translation of specific mRNAs. A profile aberrant expression of miRNAs has been linked to human diseases, including cardiovascular dysfunction.
SciELO Brasil
以上显示的是最相近的搜索结果。 查看全部搜索结果