Three decades have passed from the initial discovery of a microRNA (miRNA) in
Caenorhabditis elegans to our current understanding that miRNAs play essential roles in
regulating fundamental physiological processes and that their dysregulation can lead to
many human pathologies, including cancer. In effect, restoration of miRNA expression or
downregulation of aberrantly expressed miRNAs using miRNA mimics or anti-miRNA
inhibitors (anti-miRs/antimiRs), respectively, continues to show therapeutic potential for the …