Microbiota dysbiosis in primary Sjögren's syndrome and the ameliorative effect of hydroxychloroquine
The human microbiome plays an important role in autoimmune diseases. However, there is
limited knowledge regarding the microbiota in individuals with primary Sjögren's syndrome
(pSS). Here, we perform 16S ribosomal RNA gene sequencing of fecal, oral, and vaginal
samples from a cohort of 133 individuals with pSS, 56 with non-pSS, and 40 healthy control
(HC) individuals. Dysbiosis in the gut, oral, and vaginal microbiome is evident in patients
with pSS, and oral samples demonstrate the greatest extent of microbial variation. Multiple …
limited knowledge regarding the microbiota in individuals with primary Sjögren's syndrome
(pSS). Here, we perform 16S ribosomal RNA gene sequencing of fecal, oral, and vaginal
samples from a cohort of 133 individuals with pSS, 56 with non-pSS, and 40 healthy control
(HC) individuals. Dysbiosis in the gut, oral, and vaginal microbiome is evident in patients
with pSS, and oral samples demonstrate the greatest extent of microbial variation. Multiple …
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