Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces.
Engineering interfaces of distinct extracellular compartments mimicking native tissues are
key for in-depth in vitro studies on developmental and disease processes in biology and
medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar
collagen I networks with a multiparameter control of topology, mechanics, and composition,
and their distinct impact on triggering the directionality of cancer cell migration is
demonstrated.
key for in-depth in vitro studies on developmental and disease processes in biology and
medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar
collagen I networks with a multiparameter control of topology, mechanics, and composition,
and their distinct impact on triggering the directionality of cancer cell migration is
demonstrated.
Engineering interfaces of distinct extracellular compartments mimicking native tissues are key for in-depth in vitro studies on developmental and disease processes in biology and medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar collagen I networks with a multiparameter control of topology, mechanics, and composition, and their distinct impact on triggering the directionality of cancer cell migration is demonstrated.
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