Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and …
E Yu, PA Calvert, JR Mercer, J Harrison, L Baker… - Circulation, 2013 - Am Heart Assoc
… that mtDNA damage can promote atherosclerosis … mtDNA damage and improvement of
mitochondrial function are potential areas for new therapeutics. Biomarkers of mtDNA damage …
mitochondrial function are potential areas for new therapeutics. Biomarkers of mtDNA damage …
Mitochondrial DNA damage and atherosclerosis
PK Emma, MR Bennett - Trends in Endocrinology & Metabolism, 2014 - cell.com
… dysfunction and promotes atherosclerosis directly. In this … of the respiratory chain, reactive
oxygen species (ROS) are … -dependent and -independent pathways. Metabolic stress such …
oxygen species (ROS) are … -dependent and -independent pathways. Metabolic stress such …
Mitochondrial reactive oxygen species and risk of atherosclerosis
M Hulsmans, E Van Dooren, P Holvoet - Current atherosclerosis reports, 2012 - Springer
… and “electron leakage” can also contribute to the formation of … However, the inhibitory actions
on Wnt signaling are independent of … , accumulation of mitochondrial DNA damage, and …
on Wnt signaling are independent of … , accumulation of mitochondrial DNA damage, and …
Reactive oxygen species generation and atherosclerosis
… Disturbed flow causes ligand-independent activation of KDR, … DNA damage, plays a
protective role in atherosclerosis by … mitochondrial oxidative stress in promoting atherosclerosis. …
protective role in atherosclerosis by … mitochondrial oxidative stress in promoting atherosclerosis. …
Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis
Z Ding, S Liu, X Wang, M Khaidakov, Y Dai… - Scientific reports, 2013 - nature.com
… mitochondria can suffer damage under oxidative stress that induces endothelial dysfunction
and promotes … mtDNA that escapes autophagy cell-autonomously leads to TLR9 expression. …
and promotes … mtDNA that escapes autophagy cell-autonomously leads to TLR9 expression. …
Mitochondrial DNA damage, oxidative stress, and atherosclerosis: where there is smoke there is not always fire
SM Davidson, DM Yellon - Circulation, 2013 - Am Heart Assoc
… Such reactive oxygen species (ROS), can damage cellular proteins, membranes, and DNA.
… Some of the benefits of PPAR agonists may be shown to be via promotion of mitochondrial …
… Some of the benefits of PPAR agonists may be shown to be via promotion of mitochondrial …
The role of mitochondrial DNA damage in the development of atherosclerosis
PK Emma, MR Bennett - Free Radical Biology and Medicine, 2016 - Elsevier
… pivotal roles in producing reactive oxygen species (ROS) and … that mtDNA damage is present
and promotes atherosclerosis… independently of reactive oxygen species through effects on …
and promotes atherosclerosis… independently of reactive oxygen species through effects on …
Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis
T Shemiakova, E Ivanova, AV Grechko, EV Gerasimova… - Biomedicines, 2020 - mdpi.com
… the level of reactive oxygen species (ROS) in the cell [16]. … , which can mediate malfunctioning
of mitochondrial DNA (mtDNA), the … Antibodies to oxLDL may be independent predictors of …
of mitochondrial DNA (mtDNA), the … Antibodies to oxLDL may be independent predictors of …
Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease
JL Fetterman, M Holbrook, DG Westbrook… - Cardiovascular …, 2016 - Springer
… -mediated damage to mitochondrial DNA promotes atherosclerosis in … Our findings suggest
the independent association of both … production of mitochondrial reactive oxygen species and …
the independent association of both … production of mitochondrial reactive oxygen species and …
The role of oxidative stress in atherosclerosis
M Batty, MR Bennett, E Yu - Cells, 2022 - mdpi.com
… Excessive generation of reactive oxygen species (ROS) leads … pathogenic step in
atherosclerosis which promotes foam cell … As mitochondrial DNA (mtDNA) is located in the matrix …
atherosclerosis which promotes foam cell … As mitochondrial DNA (mtDNA) is located in the matrix …