Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and …

E Yu, PA Calvert, JR Mercer, J Harrison, L Baker… - Circulation, 2013 - Am Heart Assoc
… that mtDNA damage can promote atherosclerosismtDNA damage and improvement of
mitochondrial function are potential areas for new therapeutics. Biomarkers of mtDNA damage

Mitochondrial DNA damage and atherosclerosis

PK Emma, MR Bennett - Trends in Endocrinology & Metabolism, 2014 - cell.com
… dysfunction and promotes atherosclerosis directly. In this … of the respiratory chain, reactive
oxygen species (ROS) are … -dependent and -independent pathways. Metabolic stress such …

Mitochondrial reactive oxygen species and risk of atherosclerosis

M Hulsmans, E Van Dooren, P Holvoet - Current atherosclerosis reports, 2012 - Springer
… and “electron leakage” can also contribute to the formation of … However, the inhibitory actions
on Wnt signaling are independent of … , accumulation of mitochondrial DNA damage, and …

Reactive oxygen species generation and atherosclerosis

WN Nowak, J Deng, XZ Ruan, Q Xu - Arteriosclerosis, thrombosis …, 2017 - Am Heart Assoc
… Disturbed flow causes ligand-independent activation of KDR, … DNA damage, plays a
protective role in atherosclerosis by … mitochondrial oxidative stress in promoting atherosclerosis. …

Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

Z Ding, S Liu, X Wang, M Khaidakov, Y Dai… - Scientific reports, 2013 - nature.com
mitochondria can suffer damage under oxidative stress that induces endothelial dysfunction
and promotesmtDNA that escapes autophagy cell-autonomously leads to TLR9 expression. …

Mitochondrial DNA damage, oxidative stress, and atherosclerosis: where there is smoke there is not always fire

SM Davidson, DM Yellon - Circulation, 2013 - Am Heart Assoc
… Such reactive oxygen species (ROS), can damage cellular proteins, membranes, and DNA.
… Some of the benefits of PPAR agonists may be shown to be via promotion of mitochondrial

The role of mitochondrial DNA damage in the development of atherosclerosis

PK Emma, MR Bennett - Free Radical Biology and Medicine, 2016 - Elsevier
… pivotal roles in producing reactive oxygen species (ROS) and … that mtDNA damage is present
and promotes atherosclerosisindependently of reactive oxygen species through effects on …

Mitochondrial dysfunction and DNA damage in the context of pathogenesis of atherosclerosis

T Shemiakova, E Ivanova, AV Grechko, EV Gerasimova… - Biomedicines, 2020 - mdpi.com
… the level of reactive oxygen species (ROS) in the cell [16]. … , which can mediate malfunctioning
of mitochondrial DNA (mtDNA), the … Antibodies to oxLDL may be independent predictors of …

Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease

JL Fetterman, M Holbrook, DG Westbrook… - Cardiovascular …, 2016 - Springer
… -mediated damage to mitochondrial DNA promotes atherosclerosis in … Our findings suggest
the independent association of both … production of mitochondrial reactive oxygen species and …

The role of oxidative stress in atherosclerosis

M Batty, MR Bennett, E Yu - Cells, 2022 - mdpi.com
… Excessive generation of reactive oxygen species (ROS) leads … pathogenic step in
atherosclerosis which promotes foam cell … As mitochondrial DNA (mtDNA) is located in the matrix …