Little is known about how valvular tissues grow and remodel in response to altered loading.
In this work, we used the pregnancy state to represent a non-pathological cardiac volume
overload that distends the mitral valve (MV), using both extant and new experimental data
and a modified form of our MV structural constitutive model. We determined that there was
an initial period of permanent set-like deformation where no remodelling occurs, followed by
a remodelling phase that resulted in near-complete restoration of homeostatic tissue-level …