Modeling within-host HIV-1 dynamics and the evolution of drug resistance: trade-offs between viral enzyme function and drug susceptibility
There are many biological steps between viral infection of CD4+ T cells and the production
of HIV-1 virions. Here we incorporate an eclipse phase, representing the stage in which
infected T cells have not started to produce new virus, into a simple HIV-1 model. Model
calculations suggest that the quicker infected T cells progress from the eclipse stage to the
productively infected stage, the more likely that a viral strain will persist. Long-term treatment
effectiveness of antiretroviral drugs is often hindered by the frequent emergence of drug …
of HIV-1 virions. Here we incorporate an eclipse phase, representing the stage in which
infected T cells have not started to produce new virus, into a simple HIV-1 model. Model
calculations suggest that the quicker infected T cells progress from the eclipse stage to the
productively infected stage, the more likely that a viral strain will persist. Long-term treatment
effectiveness of antiretroviral drugs is often hindered by the frequent emergence of drug …
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