过去一年中添加的文章，按日期排序
[HTML][HTML] Aligning stem cell models and postmortem studies to query striatal neurodevelopment in schizophrenia
KJ Brennand - American Journal of Psychiatry, 2024 - Am Psychiatric Assoc
36 天前 - … report of human induced pluripotent stem cells (hiPSCs) … -specific cells of any type
could be differentiated for models … “How closely do stem cell–derived cells recapitulate those …
could be differentiated for models … “How closely do stem cell–derived cells recapitulate those …
Understanding copy number variations through their genes: a molecular view on 16p11. 2 deletion and duplication syndromes
R Leone, C Zuglian, R Brambilla… - Frontiers in Pharmacology, 2024 - frontiersin.org
42 天前 - … stem cell technologies opened the possibility to investigate neurodevelopmental
disorders using patient-derived induced pluripotent stem cells … the cellular mechanisms …
disorders using patient-derived induced pluripotent stem cells … the cellular mechanisms …
[HTML][HTML] Three-dimensional liquid metal-based neuro-interfaces for human hippocampal organoids
45 天前 - … Human hippocampal organoids (hHOs) derived from human induced pluripotent
stem cells (hiPSCs) have emerged as promising models for investigating neurodegenerative …
stem cells (hiPSCs) have emerged as promising models for investigating neurodegenerative …
Regulation of neurodevelopment and neuronal maturation by the transcription factor POU3F2
C Benoit - 2024 - dash.harvard.edu
52 天前 - … To assess the function of POU3F2 in neurodevelopment, we performed CRISPR/Cas9
mutagenesis in three human induced pluripotent stem cell lines: YZ1 (female, derived …
mutagenesis in three human induced pluripotent stem cell lines: YZ1 (female, derived …
Abnormal Neuronal Excitability and Excitatory Neurotransmission in a Human iPSC Model of 22q11. 2 Deletion Syndrome
J Guo, W Niu, B Cuthbert… - Biological …, 2024 - biologicalpsychiatryjournal.com
60 天前 - … of schizophrenia (SCZ). In this study, we investigated the functional impact of
22q11.… deletion on human cortical neurons using induced pluripotent stem cell (iPSC) models. …
22q11.… deletion on human cortical neurons using induced pluripotent stem cell (iPSC) models. …
301. Investigating Mitochondrial Phenotypes of the Schizophrenia-Associated 22q10. 2 Deletion Using Human Neural Models
M Robinette, V Faundez… - Biological …, 2024 - biologicalpsychiatryjournal.com
60 天前 - … Induced pluripotent stem cells (iPSCs) from neurotypical individuals were genetically
modified into isogenic 22qDel iPSCs using … proteins in neural progenitor cells (NPCs) and …
modified into isogenic 22qDel iPSCs using … proteins in neural progenitor cells (NPCs) and …
[HTML][HTML] Astrocytes Regulate Neuronal Network Burst Frequency Through NMDA Receptors in a Species-and Donor-Specific Manner
N Räsänen, J Tiihonen, M Koskuvi, Š Lehtonen… - … Psychiatry Global Open …, 2024 - Elsevier
86 天前 - … We found that the human induced pluripotent stem cell–derived cocultures
developed complex network bursting activity similar to neuronal cocultures with rat astrocytes. …
developed complex network bursting activity similar to neuronal cocultures with rat astrocytes. …
[HTML][HTML] Genetic contribution to microglial activation in schizophrenia
M Koskuvi, E Pörsti, T Hewitt, N Räsänen, YC Wu… - Molecular …, 2024 - nature.com
98 天前 - … healthy individuals to generate human induced pluripotent stem cell-derived microglia
… We chose to use human induced pluripotent stem cell (hiPSC) derived cell models. We …
… We chose to use human induced pluripotent stem cell (hiPSC) derived cell models. We …
… and epigenomic consequences of heterozygous loss of function mutations in AKAP11, the first large-effect shared risk gene for bipolar disorder and schizophrenia
105 天前 - … of AKAP11, particularly in human neurons. In this study, we use genome-wide
approaches to investigate such aberrations in human induced pluripotent stem cell (iPSC)-…
approaches to investigate such aberrations in human induced pluripotent stem cell (iPSC)-…
[引用][C] Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids
J Kim, IH Park - Biological Psychiatry, 2024 - biologicalpsychiatryjournal.com
109 天前 - … human brain organoids generated from patient-derived induced pluripotent stem
cells (… understanding of SCZ when using in vitro organoid models. Therefore, expanding SCZ …
cells (… understanding of SCZ when using in vitro organoid models. Therefore, expanding SCZ …