ContextMethadone hydrochloride treatment is the most common pharmacological
intervention for opioid dependence, and recent interest has focused on expanding
methadone treatment availability beyond traditional specially licensed clinics. However,
despite recommendations regarding effective dosing of methadone, controlled clinical trials
of higher-dose methadone have not been conducted. ObjectiveTo compare the relative
clinical efficacy of moderate-vs high-dose methadone in the treatment of opioid …