Modulation of antimicrobial peptide potency in stressed lipid bilayers
Physical Review Letters, 2019•APS
It is shown that the tendency of an archetypal antimicrobial peptide to insert into and
perforate a simple lipid bilayer is strongly modulated by tensile stress in the membrane. The
results, obtained through molecular dynamics simulations, have been demonstrated with
several lipid compositions and appear to be general, although quantitative details differ. The
findings imply that the potency of antimicrobial peptides may not be a purely intrinsic
chemical property and, instead, depends on the mechanical state of the target membrane.
perforate a simple lipid bilayer is strongly modulated by tensile stress in the membrane. The
results, obtained through molecular dynamics simulations, have been demonstrated with
several lipid compositions and appear to be general, although quantitative details differ. The
findings imply that the potency of antimicrobial peptides may not be a purely intrinsic
chemical property and, instead, depends on the mechanical state of the target membrane.
It is shown that the tendency of an archetypal antimicrobial peptide to insert into and perforate a simple lipid bilayer is strongly modulated by tensile stress in the membrane. The results, obtained through molecular dynamics simulations, have been demonstrated with several lipid compositions and appear to be general, although quantitative details differ. The findings imply that the potency of antimicrobial peptides may not be a purely intrinsic chemical property and, instead, depends on the mechanical state of the target membrane.
American Physical Society
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