Modulation of fibrin assembly and polymerization by the β-amyloid of Alzheimer's disease
DL Merkle, CH Cheng, FJ Castellino… - Blood coagulation & …, 1996 - journals.lww.com
Vascular deposition of amyloid beta protein (A [beta] P) is associated with recurrent
intracerebral hemorrhages in certain disease states. Based upon these findings, we studied
the effect of A [beta] P on fibrin (Fn) formation and fibrinolysis. We utilized electron
microscopy and light scattering studies to examine alterations in the nature of the Fn clots
obtained in the presence of the amyloid of Alzheimer's disease (AD), A [beta] P 1-40.
Electron microscopic analysis revealed a network of Fn and amyloid fibers formed in the …
intracerebral hemorrhages in certain disease states. Based upon these findings, we studied
the effect of A [beta] P on fibrin (Fn) formation and fibrinolysis. We utilized electron
microscopy and light scattering studies to examine alterations in the nature of the Fn clots
obtained in the presence of the amyloid of Alzheimer's disease (AD), A [beta] P 1-40.
Electron microscopic analysis revealed a network of Fn and amyloid fibers formed in the …
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