Modulation of the immunogenicity of antigenic determinants by their flanking residues
KD Moudgil, EE Sercarz, IS Grewal - Immunology today, 1998 - cell.com
KD Moudgil, EE Sercarz, IS Grewal
Immunology today, 1998•cell.comMuch of the attention on protein antigens and their induction of T-cell responses has focused
on the nature of the interactions of theircore'determinants with the major histocompatibility
complex (MHC) or the T-cell receptor (TCR). Here, Kamal Moudgil and colleagues instead
emphasize the vital role of the amino acid residues that flank the core antigenic determinant
on the outcome of the response.
on the nature of the interactions of theircore'determinants with the major histocompatibility
complex (MHC) or the T-cell receptor (TCR). Here, Kamal Moudgil and colleagues instead
emphasize the vital role of the amino acid residues that flank the core antigenic determinant
on the outcome of the response.
Abstract
Much of the attention on protein antigens and their induction of T-cell responses has focused on the nature of the interactions of their `core' determinants with the major histocompatibility complex (MHC) or the T-cell receptor (TCR). Here, Kamal Moudgil and colleagues instead emphasize the vital role of the amino acid residues that flank the core antigenic determinant on the outcome of the response.
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