Modulatory effects of antidepressant classes on the innate and adaptive immune system in depression

HA Eyre, H Lavretsky, J Kartika, A Qassim… - …, 2016 - thieme-connect.com
HA Eyre, H Lavretsky, J Kartika, A Qassim, BT Baune
Pharmacopsychiatry, 2016thieme-connect.com
Current reviews exploring for unique immune-modulatory profiles of antidepressant classes
are limited by focusing mainly on cytokine modulation only and neglecting other aspects of
the innate and adaptive immune system. These reviews also do not include recent
comparative clinical trials, immune-genetic studies and therapeutics with unique
neurotransmitter profiles (eg, agomelatine). This systematic review extends the established
literature by comprehensively reviewing the effects of antidepressants classes on both the …
Current reviews exploring for unique immune-modulatory profiles of antidepressant classes are limited by focusing mainly on cytokine modulation only and neglecting other aspects of the innate and adaptive immune system. These reviews also do not include recent comparative clinical trials, immune-genetic studies and therapeutics with unique neurotransmitter profiles (e. g., agomelatine). This systematic review extends the established literature by comprehensively reviewing the effects of antidepressants classes on both the innate and adaptive immune system. Antidepressants appear, in general, to reduce pro-inflammatory factor levels, particularly C-reactive protein (CRP), tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6. We caution against conclusions as to which antidepressant possesses the greater anti-inflammatory effect, given the methodological heterogeneity among studies and the small number of comparative studies. The effects of antidepressant classes on adaptive immune factors are complex and poorly understood, and few studies have been conducted. Methodological heterogeneity is high among these studies (e. g., length of study, cohort characteristics, dosage used and immune marker analysis). We recommend larger, comparative studies – in clinical and pre-clinical populations.
Thieme Connect
以上显示的是最相近的搜索结果。 查看全部搜索结果