Modulatory effects of autophagy on APP processing as a potential treatment target for Alzheimer's disease
Alzheimer's disease (AD) is characterized by the formation of intracellular aggregate
composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-β (Aβ)
plaques derived from proteolysis cleavage of amyloid precursor protein (APP). Autophagy
refers to the lysosomal-mediated degradation of cytoplasmic constituents, which plays a
critical role in maintaining cellular homeostasis. Importantly, recent studies reported that
dysregulation of autophagy is associated in the pathogenesis of AD, and therefore …
composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-β (Aβ)
plaques derived from proteolysis cleavage of amyloid precursor protein (APP). Autophagy
refers to the lysosomal-mediated degradation of cytoplasmic constituents, which plays a
critical role in maintaining cellular homeostasis. Importantly, recent studies reported that
dysregulation of autophagy is associated in the pathogenesis of AD, and therefore …
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