Molecular components of a cell death pathway activated by endoplasmic reticulum stress
RV Rao, KS Poksay, S Castro-Obregon… - Journal of Biological …, 2004 - ASBMB
Alterations in Ca 2+ homeostasis and accumulation of misfolded proteins in the
endoplasmic reticulum (ER) cause ER stress that ultimately leads to programmed cell death.
Recent studies have shown that ER stress triggers programmed cell death via an alternative
intrinsic pathway of apoptosis that, unlike the intrinsic pathway described previously, is
independent of Apaf-1 and cytochrome c. In the present work, we have used a set of
complementary approaches, including two-dimensional gel electrophoresis coupled with …
endoplasmic reticulum (ER) cause ER stress that ultimately leads to programmed cell death.
Recent studies have shown that ER stress triggers programmed cell death via an alternative
intrinsic pathway of apoptosis that, unlike the intrinsic pathway described previously, is
independent of Apaf-1 and cytochrome c. In the present work, we have used a set of
complementary approaches, including two-dimensional gel electrophoresis coupled with …
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