Molecular determinants of plaque size as an indicator of dengue virus attenuation
The development of live viral vaccines relies on empirically derived phenotypic criteria,
especially small plaque sizes, to indicate attenuation. However, while some candidate
vaccines successfully translated into licensed applications, others have failed safety trials,
placing vaccine development on a hit-or-miss trajectory. We examined the determinants of
small plaque phenotype in two dengue virus (DENV) vaccine candidates, DENV-3
PGMK30FRhL3, which produced acute febrile illness in vaccine recipients and DENV-2 …
especially small plaque sizes, to indicate attenuation. However, while some candidate
vaccines successfully translated into licensed applications, others have failed safety trials,
placing vaccine development on a hit-or-miss trajectory. We examined the determinants of
small plaque phenotype in two dengue virus (DENV) vaccine candidates, DENV-3
PGMK30FRhL3, which produced acute febrile illness in vaccine recipients and DENV-2 …
以上显示的是最相近的搜索结果。 查看全部搜索结果