Molecular evolution of the mouse proline-rich protein multigene family. Insertion of a long interspersed repeated DNA element.
DK Ann, MK Smith, DM Carlson - Journal of Biological Chemistry, 1988 - ASBMB
Proline-rich proteins (PRPs) in the salivary glands of mice, rats, and hamsters are encoded
by tissue-specific inducible multigene families. Mouse PRP genes are located on
chromosome 8, and transcription is dramatically induced (about 70-fold) by isoproterenol
treatment. Clones containing two nonallelic PRP genes (MP2 and M14) were isolated from
cosmid and phage libraries of CD-1 mouse genomic DNA. The cloned regions comprise a
contiguous block of 77 kilobase pairs of the mouse genome. Restriction mapping …
by tissue-specific inducible multigene families. Mouse PRP genes are located on
chromosome 8, and transcription is dramatically induced (about 70-fold) by isoproterenol
treatment. Clones containing two nonallelic PRP genes (MP2 and M14) were isolated from
cosmid and phage libraries of CD-1 mouse genomic DNA. The cloned regions comprise a
contiguous block of 77 kilobase pairs of the mouse genome. Restriction mapping …
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