Subretinal fibrosis is a result of a wound healing response that follows choroidal
neovascularization in neovascular age-related macular degeneration (nAMD). Although anti-
vascular endothelial growth factor therapy has become a standard treatment that improves
visual acuity in many nAMD patients, unsuccessful treatment outcomes have often been
attributed to the progression of subretinal fibrosis. In this review, we summarize the cellular
and extracellular components of subretinal fibrous membranes and also discuss the …