过去一年中添加的文章，按日期排序
Targeting CDK1/2-driven mechanisms of resistance to BRAF and EGFR inhibition in BRAF (V600E) colorectal cancer restores therapeutic response
JP Coppe, DP Muñoz, CE Atreya, Y Hwang… - Cancer Research, 2024 - AACR
135 天前 - … of ERK signaling by inducing adaptive transcriptional changes via beta-… kinase
families, and integrated these profiles using computational methods to model signaling pathways…
families, and integrated these profiles using computational methods to model signaling pathways…
Spatial profiling of human colorectal cancer brain metastasis identifies chromosomal instability with adaptive niche cellular reorganization and reprograming
A Sathe, A Khan, JI Kang, R Meka, SM Grimes… - Cancer Research, 2024 - AACR
135 天前 - … Despite elevated signaling pathway activity, metastatic tumor cells were resistant …
kinase inhibitor. In contrast, pirfenidone, an anti-fibrotic and anti-inflammatory small molecule, …
kinase inhibitor. In contrast, pirfenidone, an anti-fibrotic and anti-inflammatory small molecule, …
Osimertinib-induced epigenetic and transcriptional reprogramming drives a BRD4-POUF-PDGFRB-YAP-EMT axis of resistance in NSCLC
135 天前 - … Moreover, it is well known that cancer cells escape tyrosine kinase inhibitor (TKI) …
-opting PDGFRβ signaling to activate YAP/TEAD and ERK1/2 as a means of driving adaptive …
-opting PDGFRβ signaling to activate YAP/TEAD and ERK1/2 as a means of driving adaptive …
Identifying synthetic lethalities in GCN2 KO tumors using an in vivo targeted CRISPRi screen
NR Sommers, RA Cordova, AJ Klunk, RC Wek… - Cancer Research, 2024 - AACR
135 天前 - … The integrated stress response (ISR) is an intracellular signaling pathway that
fosters cell adaptation to diverse stresses. The ISR is mediated by a family of four eIF2 kinases …
fosters cell adaptation to diverse stresses. The ISR is mediated by a family of four eIF2 kinases …
Ciblage de la machinerie traductionnelle pour surmonter la résistance aux inhibiteurs de kinase dans le mélanome
M Takdenti - 2024 - papyrus.bib.umontreal.ca
185 天前 - … de kinase (IKs) et d’en empêcher l’adaptation et la reprogrammation métabolique?
… to kinase inhibitors (KIs) and we seek to dissect the underlying molecular mechanisms. …
… to kinase inhibitors (KIs) and we seek to dissect the underlying molecular mechanisms. …
Abstract C141: Targeting SHP2-dependent adaptive resistance to BRAF and MEK inhibition in gliomas
247 天前 - … However, responses are incomplete and can be short… kinome re-programming,
treatment-emergent resistance mutations, and adaptive resistance, by which upstream signaling …
treatment-emergent resistance mutations, and adaptive resistance, by which upstream signaling …
Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers–Targeting PERK as a novel therapeutic strategy for …
249 天前 - … protein response (UPR) is a cellular stress response … The UPR is an adaptive
signaling pathway which is highly … , including cAMP response element-binding protein kinase (…
signaling pathway which is highly … , including cAMP response element-binding protein kinase (…
SHP2 Inhibition Overcomes Adaptive and Acquired Resistance to FLT3 TKI to Improve Efficacy Against FLT3/ITD AML
T Seale, L Li, JK Bruner, B Nguyen, MJ Levis… - Blood, 2023 - Elsevier
250 天前 - … target for treatment with tyrosine kinase inhibitors (TKI), … rapid signal reprogramming
known as adaptive resistance … RTKs suggests that targeting a signaling hub that inhibits …
known as adaptive resistance … RTKs suggests that targeting a signaling hub that inhibits …
983 Syk promotes macrophage immunosuppressive phenotype to suppress anti-tumor immunity
277 天前 - … inhibition of adaptive immune responses in cancer. Hence, targeting signaling
pathways … kinase or use of FDA-approved Syk inhibitor R788 (aka, fostamatinib), activates NFkB …
pathways … kinase or use of FDA-approved Syk inhibitor R788 (aka, fostamatinib), activates NFkB …
Identifying Gene-Treatment Interactions and Targetable Radiation Vulnerabilities in Glioblastoma through Coupling of In Vivo CRISPR Perturbation and Single Cell …
SJ Liu, J Pak, C Zou, E Payne, K Foster… - International Journal of …, 2023 - redjournal.org
309 天前 - … , the catalytic subunit of DNA-dependent protein kinase (DNA-PK), as a radiotherapy
… that is targetable using small molecules. These tools are adaptable for a wide range of …
… that is targetable using small molecules. These tools are adaptable for a wide range of …