Molecular targeting of growth factor receptor-bound 2 (Grb2) as an anti-cancer strategy
PG Dharmawardana, B Peruzzi, A Giubellino… - Anti-cancer …, 2006 - journals.lww.com
Growth factor receptor-bound 2 (Grb2) is a ubiquitously expressed adapter protein that
provides a critical link between cell surface growth factor receptors and the Ras signaling
pathway. As such, it has been implicated in the oncogenesis of several important human
malignancies. In addition to this function, research over the last decade has revealed other
fundamental roles for Grb2 in cell motility and angiogenesis–processes that also contribute
to tumor growth, invasiveness and metastasis. This functional profile makes Grb2 a high …
provides a critical link between cell surface growth factor receptors and the Ras signaling
pathway. As such, it has been implicated in the oncogenesis of several important human
malignancies. In addition to this function, research over the last decade has revealed other
fundamental roles for Grb2 in cell motility and angiogenesis–processes that also contribute
to tumor growth, invasiveness and metastasis. This functional profile makes Grb2 a high …