Molecular monitoring

S Soverini, G Rosti, M Baccarani… - Current hematologic …, 2014 - Springer
… , real time quantitative polymerase chain reaction (RQ-PCR) … of semi-quantitative, competitive
RT-PCR approaches, … nilotinib efficacy and safety in clinical trials newly diagnosed patients

Limited clinical value of regular bone marrow cytogenetic analysis in imatinib-treated chronic phase CML patients monitored by RQ-PCR for BCR-ABL

DM Ross, S Branford, S Moore, TP Hughes - Leukemia, 2006 - nature.com
… RNA quality and reverse transcription efficiency. The results were reported … chronic
myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain

Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance

A Hochhaus, P La Rosée - Leukemia, 2004 - nature.com
… CP CML patients in whom interferon-alpha (IFN) therapypolymerase chain reaction should
not replace conventional cytogenetics for monitoring patients with chronic myeloid leukemia

Standardization of preanalytical factors for minimal residual disease analysis in chronic myelogenous leukemia

MC Müller, T Hördt, P Paschka, K Merx… - Acta …, 2004 - karger.com
… real-time quantitative polymerase chain reaction (RQ-PCR) … of PCR monitoring in other
leukemic disorders calls for the … after interferon-alpha therapy for chronic myelogenous leukemia: …

Natural history and staging of chronic myelogenous leukemia

J Cortes - Hematology/Oncology Clinics, 2004 - hemonc.theclinics.com
… Result of interferon-alpha therapy in patients with chronic … In this study, CML patients who
were treated with allogeneic bone marrow transplantation initially were classified according to …

Correlations between cytogenetic and molecular monitoring among patients with newly diagnosed chronic myeloid leukemia in chronic phase: post hoc analyses of …

LP Akard, JE Cortes, M Albitar… - … of Pathology & …, 2014 - meridian.allenpress.com
… transcriptase polymerase chain reaction using BM and PB. … reverse transcriptase polymerase
chain reaction using PB or BM (all … had Eastern Cooperative Oncology Group performance

Chronic myeloid leukemia: diagnosis and treatment

A Quintás-Cardama, JE Cortes - Mayo Clinic Proceedings, 2006 - Elsevier
… to CML-AP is usually subclinical, and laboratory monitoring … , using reverse
transcriptase-polymerase chain reaction (RT-… -competitive manner may represent an alternative for …

Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International …

TP Hughes, A Hochhaus, S Branford… - Blood, The Journal …, 2010 - ashpublications.org
… significance of monitoring BCR-ABL transcripts by real-time quantitative polymerase chain
reaction (… pretreated with interferon alpha. Low levels of residual disease are associated with …

The effect of total-ABL, GUS and B2M control genes on BCR-ABL monitoring by real-time RT-PCR

J Rulcová, V Zmeková, Z Zemanová, H Klamová… - Leukemia research, 2007 - Elsevier
… real-time method with the results of competitive RT-PCR [7] used … represent the type of
treatment: IFN, interferon alpha; STI, … reverse-transcriptase polymerase chain reaction (RQ-PCR)—…

Molecular methods in diagnosis and monitoring of haematological malignancies

DT Yeung, WT Parker, S Branford - Pathology-Journal of the …, 2011 - journals.lww.com
… Summary: The use of the polymerase chain reaction (PCR) was … Historically, treatment
efficacy in CML was assessed using … as real-time quantitative polymerase chain reaction (RQ-PCR…