Mosaic chromosome Y loss is associated with alterations in blood cell counts in UK Biobank men
Mosaic loss of Y chromosome (mLOY) is the most frequently detected somatic copy number
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential
mechanism linking mLOY to disease risk in 206,353 UK males. Associations between
mLOY, detected by genotyping arrays, and blood cell counts were assessed by multivariable
linear models adjusted for relevant risk factors. Among the participants, mLOY was detected
in 39,809 men. We observed associations between mLOY and reduced erythrocyte count …
alteration in leukocytes of men. In this study, we investigate blood cell counts as a potential
mechanism linking mLOY to disease risk in 206,353 UK males. Associations between
mLOY, detected by genotyping arrays, and blood cell counts were assessed by multivariable
linear models adjusted for relevant risk factors. Among the participants, mLOY was detected
in 39,809 men. We observed associations between mLOY and reduced erythrocyte count …
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