Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non–small-cell lung cancer patients with brain …
MP Mehta, WR Shapiro, SC Phan, R Gervais… - International Journal of …, 2009 - Elsevier
PURPOSE: To determine the efficacy of motexafin gadolinium (MGd) in combination with
whole brain radiotherapy (WBRT) for the treatment of brain metastases from non–small-cell
lung cancer. METHODS AND MATERIALS: In an international, randomized, Phase III study,
patients with brain metastases from non–small-cell lung cancer were randomized to WBRT
with or without MGd. The primary endpoint was the interval to neurologic progression,
determined by a centralized Events Review Committee who was unaware of the treatment …
whole brain radiotherapy (WBRT) for the treatment of brain metastases from non–small-cell
lung cancer. METHODS AND MATERIALS: In an international, randomized, Phase III study,
patients with brain metastases from non–small-cell lung cancer were randomized to WBRT
with or without MGd. The primary endpoint was the interval to neurologic progression,
determined by a centralized Events Review Committee who was unaware of the treatment …
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