Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications
Much has been learnt about the mechanisms of thymic self‐tolerance induction from work on
both the rare autosomal recessive disease autoimmune polyendocrinopathy candidiasis
ectodermal dystrophy (APECED) and the autoimmune regulator (AIRE) protein mutated in
this disease. Normally, AIRE drives low‐level expression of huge numbers of peripheral
tissue‐specific antigens (TSAgs) in medullary thymic epithelial cells (mTECs), leading to the
deletion of TSAg‐reactive thymocytes maturing nearby. The very recently discovered …
both the rare autosomal recessive disease autoimmune polyendocrinopathy candidiasis
ectodermal dystrophy (APECED) and the autoimmune regulator (AIRE) protein mutated in
this disease. Normally, AIRE drives low‐level expression of huge numbers of peripheral
tissue‐specific antigens (TSAgs) in medullary thymic epithelial cells (mTECs), leading to the
deletion of TSAg‐reactive thymocytes maturing nearby. The very recently discovered …
Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinic and pathogenetic implications
Much has been learnt about the mechanisms of thymic self-tolerance induction from work on
both the rare autosomal recessive disease autoimmune polyendocrinopathy candidiasis
ectodermal dystrophy (APECED) and the autoimmune regulator (AIRE) protein mutated in
this disease. Normally, AIRE drives low-level expression of huge numbers of peripheral
tissue-specific antigens (TSAgs) in medullary thymic epithelial cells (mTECs), leading to the
deletion of TSAg-reactive thymocytes maturing nearby. The very recently discovered …
both the rare autosomal recessive disease autoimmune polyendocrinopathy candidiasis
ectodermal dystrophy (APECED) and the autoimmune regulator (AIRE) protein mutated in
this disease. Normally, AIRE drives low-level expression of huge numbers of peripheral
tissue-specific antigens (TSAgs) in medullary thymic epithelial cells (mTECs), leading to the
deletion of TSAg-reactive thymocytes maturing nearby. The very recently discovered …
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