Multidrug resistance (MDR) and collateral sensitivity in bacteria, with special attention to genetic and evolutionary aspects and to the perspectives of antimicrobial …
Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are
discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era”
are evaluated. In commensal niches, the appearance of a new antibiotic resistance often
reduces fitness, but compensatory mutations may counteract this tendency. The appearance
of new antibiotic resistance is frequently accompanied by a collateral sensitivity to other …
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are
discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era”
are evaluated. In commensal niches, the appearance of a new antibiotic resistance often
reduces fitness, but compensatory mutations may counteract this tendency. The appearance
of new antibiotic resistance is frequently accompanied by a collateral sensitivity to other …
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