Mutant NPM1 hijacks transcriptional hubs to maintain pathogenic gene programs in acute myeloid leukemia
Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with a wide range of
biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is
often found mutated, resulting in the addition of a nuclear export signal and a shift of the
protein to the cytoplasm (NPM1c). AMLs carrying this mutation have aberrant expression of
the HOXA/B genes, whose overexpression leads to leukemogenic transformation. Here, for
the first time, we comprehensively prove that NPM1c binds to a subset of active gene …
biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is
often found mutated, resulting in the addition of a nuclear export signal and a shift of the
protein to the cytoplasm (NPM1c). AMLs carrying this mutation have aberrant expression of
the HOXA/B genes, whose overexpression leads to leukemogenic transformation. Here, for
the first time, we comprehensively prove that NPM1c binds to a subset of active gene …
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