Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme
JL Foo, CJ Jackson, PD Carr, HK Kim… - Biochemical …, 2010 - portlandpress.com
The metal ion co-ordination sites of many metalloproteins have been characterized by a
variety of spectroscopic techniques and small-molecule model systems, revealing many
important insights into the structural determinants of metal ion co-ordination. However, our
understanding of this fundamentally and practically important phenomenon remains
frustratingly simplistic; in many proteins it is essentially impossible to predict metal ion
specificity and the effects of remote 'outer-shell'residues on metal ion co-ordination strength …
variety of spectroscopic techniques and small-molecule model systems, revealing many
important insights into the structural determinants of metal ion co-ordination. However, our
understanding of this fundamentally and practically important phenomenon remains
frustratingly simplistic; in many proteins it is essentially impossible to predict metal ion
specificity and the effects of remote 'outer-shell'residues on metal ion co-ordination strength …
Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme.
FJL Foo JeeLoon, CJ Jackson, PD Carr… - 2010 - cabidigitallibrary.org
The metal ion co-ordination sites of many metalloproteins have been characterized by a
variety of spectroscopic techniques and small-molecule model systems, revealing many
important insights into the structural determinants of metal ion co-ordination. However, our
understanding of this fundamentally and practically important phenomenon remains
frustratingly simplistic; in many proteins it is essentially impossible to predict metal ion
specificity and the effects of remote'outer-shell'residues on metal ion co-ordination strength …
variety of spectroscopic techniques and small-molecule model systems, revealing many
important insights into the structural determinants of metal ion co-ordination. However, our
understanding of this fundamentally and practically important phenomenon remains
frustratingly simplistic; in many proteins it is essentially impossible to predict metal ion
specificity and the effects of remote'outer-shell'residues on metal ion co-ordination strength …
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