Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell population
comprised of immature myeloid cells and myeloid progenitors with very potent
immunosuppressive potential. MDSCs are reported to be abundant in the lungs of active
tuberculosis (TB) patients. We sought to perform an in-depth study of MDSCs during latent
TB infection (LTBI) and active TB (ATB) using the nonhuman primate (NHP) model of
pulmonary TB. We found a higher proportion of granulocytic, polymorphonuclear myeloid …