Myosin waves and a mechanical asymmetry guide the oscillatory migration of Drosophila cardiac progenitors
N Balaghi, G Erdemci-Tandogan, C McFaul… - Developmental Cell, 2023 - cell.com
N Balaghi, G Erdemci-Tandogan, C McFaul, R Fernandez-Gonzalez
Developmental Cell, 2023•cell.comHeart development begins with the formation of a tube as cardiac progenitors migrate from
opposite sides of the embryo. Abnormal cardiac progenitor movements cause congenital
heart defects. However, the mechanisms of cell migration during early heart development
remain poorly understood. Using quantitative microscopy, we found that in Drosophila
embryos, cardiac progenitors (cardioblasts) migrated through a sequence of forward and
backward steps. Cardioblast steps were associated with oscillatory non-muscle myosin II …
opposite sides of the embryo. Abnormal cardiac progenitor movements cause congenital
heart defects. However, the mechanisms of cell migration during early heart development
remain poorly understood. Using quantitative microscopy, we found that in Drosophila
embryos, cardiac progenitors (cardioblasts) migrated through a sequence of forward and
backward steps. Cardioblast steps were associated with oscillatory non-muscle myosin II …
Summary
Heart development begins with the formation of a tube as cardiac progenitors migrate from opposite sides of the embryo. Abnormal cardiac progenitor movements cause congenital heart defects. However, the mechanisms of cell migration during early heart development remain poorly understood. Using quantitative microscopy, we found that in Drosophila embryos, cardiac progenitors (cardioblasts) migrated through a sequence of forward and backward steps. Cardioblast steps were associated with oscillatory non-muscle myosin II waves that induced periodic shape changes and were necessary for timely heart tube formation. Mathematical modeling predicted that forward cardioblast migration required a stiff boundary at the trailing edge. Consistent with this, we found a supracellular actin cable at the trailing edge of the cardioblasts that limited the amplitude of the backward steps, thus biasing the direction of cell movement. Our results indicate that periodic shape changes coupled with a polarized actin cable produce asymmetrical forces that promote cardioblast migration.
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