NF-κB transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: a role for peptidyl-prolyl isomerase activity
AG Erlejman, SA De Leo, GI Mazaira… - Journal of Biological …, 2014 - ASBMB
Hsp90 binding immunophilins FKBP51 and FKBP52 modulate steroid receptor trafficking
and hormone-dependent biological responses. With the purpose to expand this model to
other nuclear factors that are also subject to nuclear-cytoplasmic shuttling, we analyzed
whether these immunophilins modulate NF-κB signaling. It is demonstrated that FKBP51
impairs both the nuclear translocation rate of NF-κB and its transcriptional activity. The
inhibitory action of FKBP51 requires neither the peptidylprolyl-isomerase activity of the …
and hormone-dependent biological responses. With the purpose to expand this model to
other nuclear factors that are also subject to nuclear-cytoplasmic shuttling, we analyzed
whether these immunophilins modulate NF-κB signaling. It is demonstrated that FKBP51
impairs both the nuclear translocation rate of NF-κB and its transcriptional activity. The
inhibitory action of FKBP51 requires neither the peptidylprolyl-isomerase activity of the …
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