… Such opposing activities of NO during the cardiac cycle, perhaps achieved by
coordinated actions of different NOS isoforms, would facilitate cardiac performance. In
addition, subtle modulatory effects of NO, such as regulation of ATP production by
mitochondrial NOS, would not be identified in the tests used by Vandecasteele et al. The
physical and functional linkages between the different isoforms of … These subtle effects of
NO-related molecules reflect a principal role in signaling, which if not obligatory, is likely to …