… of the chemopreventive properties of nonsteroidal anti-inflammatory drugs (NSAIDs) against
… It examines how mechanistic data have been used to develop safer chemopreventive …

… clearly demonstrated that NSAID treatment caused … NSAIDs as chemopreventive agents
in colorectal cancer and discusses the direction of ongoing clinical studies evaluating NSAIDs …

… of statins and NSAIDs as a promising regimen for cancer chemoprevention. Although the
existing … cancer, the combination of statins and NSAIDs may also be useful for the prevention of …

… The current review will assess the evidence supporting a chemopreventive effect of NSAIDs
… a chemopreventive effect, we will review site-specific data regarding chemoprevention of …

… mechanisms of NSAID chemoprevention also exists. NSAIDs induce apoptosis in cells
lacking COX-2,31,56 and prostaglandins do not rescue cells from NSAIDsinduced apoptosis.Also…

… The mechanism of NSAID chemoprevention appears to be related, at least in part, to COX-2
inhibition. Consider studies in the Min/ mouse model of FAP. The Min/ mouse carries a …

… , prospective, and interventional studies of NSAIDs and melanoma risk have yielded … of
NSAIDs for melanoma chemoprevention. This mini-review highlights current knowledge of NSAID …

… the evidence on the effect of aspirin and NSAIDs on breast cancer chemoprevention. …
chemopreventive activity of NSAIDs. As outlined in this review, salicylates and the other NSAIDs …

… In high risk cohorts where NSAID chemoprevention trials appear justifiable, additional … risk
of NSAID toxicity. These could include the use of enteric coated aspirin, NSAIDs with excellent …

… as clinical studies typically demonstrate chemopreventive efficacy of NSAIDs only at doses
… Additional in vivo evidence for COX-independent mechanisms of NSAID chemoprevention …