Near-infrared light-responsive core–shell nanogels for targeted drug delivery
H Kang, AC Trondoli, G Zhu, Y Chen, YJ Chang… - ACS …, 2011 - ACS Publications
ACS nano, 2011•ACS Publications
A near-infrared light-responsive drug delivery platform based on Au–Ag nanorods (Au–Ag
NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity
has been applied to develop a polyacrylamide-based sol–gel transition system to
encapsulate anticancer drugs into the gel scaffold. The Au–Ag NR-based nanogels can also
be readily functionalized with targeting moieties, such as aptamers, for specific recognition
of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au–Ag NRs …
NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity
has been applied to develop a polyacrylamide-based sol–gel transition system to
encapsulate anticancer drugs into the gel scaffold. The Au–Ag NR-based nanogels can also
be readily functionalized with targeting moieties, such as aptamers, for specific recognition
of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au–Ag NRs …
A near-infrared light-responsive drug delivery platform based on Au–Ag nanorods (Au–Ag NRs) coated with DNA cross-linked polymeric shells was constructed. DNA complementarity has been applied to develop a polyacrylamide-based sol–gel transition system to encapsulate anticancer drugs into the gel scaffold. The Au–Ag NR-based nanogels can also be readily functionalized with targeting moieties, such as aptamers, for specific recognition of tumor cells. When exposed to NIR irradiation, the photothermal effect of the Au–Ag NRs leads to a rapid rise in the temperature of the surrounding gel, resulting in the fast release of the encapsulated payload with high controllability. In vitro study confirmed that aptamer-functionalized nanogels can be used as drug carriers for targeted drug delivery with remote control capability by NIR light with high spatial/temporal resolution.
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