In the present study, a series of new carbazole linked 1 H-1, 2, 3-triazoles (2–27) were
synthesized via click reaction of N-propargyl-9H-carbazole (1) and azides of appropriate
acetophenones and heterocycles. Synthesized carbazole triazoles including 7, 9, 10, 19, 20,
and 23–26 (IC 50= 0.8±0.01–100.8±3.6 μM), exhibited several folds more potent α-
glucosidase inhibitory in vitro activity as compared to standard drug, acarbose. Compounds
2–5, 7–13, and 17–27 did not show any cytotoxicity against 3T3 cell lines, except triazoles 6 …

In the present study, a series of new carbazole linked 1H-1, 2, 3-triazoles (2-27) were
synthesized via click reaction of N-propargyl-9H-carbazole (1) and azides of appropriate
acetophenones and heterocycles. Synthesized carbazole triazoles including 7, 9, 10, 19, 20,
and 23-26 (IC50= 0.8±0.01-100.8±3.6 μM), exhibited several folds more potent α-
glucosidase inhibitory in vitro activity as compared to standard drug, acarbose. Compounds
2-5, 7-13, and 17-27 did not show any cytotoxicity against 3T3 cell lines, except triazoles 6 …