… Like our previously published reviews on new drug approvals … clinical applications and
synthetic methods of 29 small molecule drugs approved by the FDA in 2021, but excludes new …

… , and extended clinical applications. Similar to our previous reviews about the new drug
approvals in 2019–2021, 25-27 we will summarize the clinical indications, mechanism of actions …

… for researchers involved in new drug research and development by presenting the clinical
applications and synthesis methods of 29 newly approved drugs by the FDA in 2023. The …

… to outline the clinical applications and synthetic methods of 19 NCEs newly approved by the
FDA in … Compared with the 50 drugs approved by the FDA in 2021 (36 NCEs and 14 NBEs), …

… new drug approval during 2019 [22], this review will focus on the clinical applications and
synthetic methods of 34 small molecules approved by the FDA in 2020 (Fig. 1), but excludes …

… across the world until 2020, we provide the synthesis routes originally used during … applications.
In the last section, we also provide an update on kinase inhibitor drugs approved in 2021…

… heterocycles may be used to discover new drugs with similar biological targets and …
applications and synthetic routes of 22 approved pyrimidine-fused bicyclic heterocyclic drugs in clinic…

… Thirteen new fluorinated drugs were approved by the FDA in 2020 for … and -Cl in drugs.
Moreover, we will provide the chemical synthesis of the 14 approved halogenated drugs in 2021. …

… Administration (FDA). Quite the contrary, with a … new drugs, 2021 belongs to the most
successful FDA years. We assign these new drugs to one of three levels of innovation: (1) first drug …

… by the US Food and Drug Administration (FDA) 4, 5. The aim of this review is to highlight the
novel small molecule drug approvals in oncology during the period 2021–2022. This review …